InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Polh

Summary

InnateDB Gene

IDBG-186157.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polh

Gene Name

polymerase (DNA directed), eta (RAD 30 related)

Synonyms

RAD30A; XPV

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023953

Encoded Proteins

IDBP-186159

polymerase (DNA directed), eta (RAD 30 related)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170734:
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:46172004-46202625

Strand

Reverse strand

Band

Transcripts

ENSMUST00000024749

ENSMUSP00000024749

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000731	DNA synthesis involved in DNA repair
GO:0006261	DNA-dependent DNA replication
GO:0006281	DNA repair
GO:0006290	pyrimidine dimer repair
GO:0006301	postreplication repair
GO:0010225	response to UV-C

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000170734

View Gene Order

ENSBTAG00000006015

Not yet available

Pathways

NETPATH

REACTOME

REACT_233397

DNA Repair pathway

REACT_218307

Translesion synthesis by DNA polymerases bypassing lesion on DNA template pathway

REACT_218503

Translesion synthesis by Pol eta pathway

REACT_226050

DNA Damage Bypass pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_1287

Translesion synthesis by Pol eta pathway

REACT_2198

Translesion synthesis by DNA polymerases bypassing lesion on DNA template pathway

REACT_2174

DNA Damage Bypass pathway

REACT_216

DNA Repair pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.311585

RefSeq

NM_030715

OMIM

CCDS

CCDS28822

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas