InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATG5

Summary

InnateDB Gene

IDBG-631895.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATG5

Gene Name

Autophagy protein 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005400

Encoded Proteins

IDBP-683479

Autophagy protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 17709747

[Homo sapiens] ATG5 forms a conjugate with ATG12 to directly associate with DDX58 and MAVS and negatively regulate the antiviral IFN production pathway by mediating autophagy.

PMID 17921696

[Homo sapiens] ATG12::ATG5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. ATG12::ATG5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.

PMID 17921696

[Mus musculus] Atg12::Atg5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. Atg12::Atg5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.

PMID 25650776

[Mus musculus] Atg5 knockout mice develop systemic and hepatic inflammation with high-fat diet and low-dose lipolysaccharide treatment.

PMID 26649827

[Mus musculus] Atg5 plays a unique role in protection against M. tuberculosis by preventing polymorphic mononuclear cell (PMN)-mediated immunopathology. Loss of Atg5 in PMNs can cause susceptibility to M. tuberculosis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057663:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:44166445-44204874

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007100

ENSBTAP00000007100

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0001974	blood vessel remodeling
GO:0002376	immune system process
GO:0002739	regulation of cytokine secretion involved in immune response
GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0009620	response to fungus
GO:0031397	negative regulation of protein ubiquitination
GO:0039689	negative stranded viral RNA replication
GO:0042311	vasodilation
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043687	post-translational protein modification
GO:0045087	innate immune response
GO:0048840	otolith development
GO:0055015	ventricular cardiac muscle cell development
GO:0060047	heart contraction
GO:1902017	regulation of cilium assembly