Bos taurus Protein: ATG5
Summary
InnateDB Protein IDBP-683479.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG5
Protein Name Autophagy protein 5
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007100
InnateDB Gene IDBG-631895 (ATG5)
Protein Structure
UniProt Annotation
Function Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12- ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway (By similarity). {ECO:0000250}.May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma- induced autophagic cell death by interacting with FADD (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.
Predicted by orthology
Total 91 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0001974 blood vessel remodeling
GO:0002376 immune system process
GO:0002739 regulation of cytokine secretion involved in immune response
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0009620 response to fungus
GO:0031397 negative regulation of protein ubiquitination
GO:0039689 negative stranded viral RNA replication
GO:0042311 vasodilation
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0045087 innate immune response
GO:0048840 otolith development
GO:0055015 ventricular cardiac muscle cell development
GO:0060047 heart contraction
GO:1902017 regulation of cilium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0005930 axoneme
GO:0016020 membrane
GO:0034045 pre-autophagosomal structure membrane
Protein Structure and Domains
PDB ID
InterPro IPR007239 Autophagy-related protein 5
PFAM PF04106
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3MQ24
PhosphoSite PhosphoSite-
TrEMBL G8JKW2
UniProt Splice Variant
Entrez Gene 532686
UniGene
RefSeq NP_001029751
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AM086994 BC102770 DAAA02025978 DAAA02025979
GenPept AAI02771 CAJ31263