Bos taurus Gene: SCARB1
Summary
InnateDB Gene IDBG-631911.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCARB1
Gene Name Scavenger receptor class B member 1
Synonyms CD36L1
Species Bos taurus
Ensembl Gene ENSBTAG00000014269
Encoded Proteins
Scavenger receptor class B member 1
Scavenger receptor class B member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] SCARB1 regulates the macrophage inflammatory response to LPS. (Demonstrated in mice)
[Mus musculus] Scarb1 regulates the macrophage inflammatory response to LPS.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073060:
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:53180927-53273723
Strand Forward strand
Band
Transcripts
ENSBTAT00000016321 ENSBTAP00000016321
ENSBTAT00000018959 ENSBTAP00000018959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0001875 lipopolysaccharide receptor activity
GO:0005515 protein binding
GO:0008035 high-density lipoprotein particle binding
GO:0030169 low-density lipoprotein particle binding
GO:0034185 apolipoprotein binding
GO:0034186 apolipoprotein A-I binding
GO:0070506 high-density lipoprotein particle receptor activity
Biological Process
GO:0001935 endothelial cell proliferation
GO:0006707 cholesterol catabolic process
GO:0006898 receptor-mediated endocytosis
GO:0007155 cell adhesion
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010886 positive regulation of cholesterol storage
GO:0010899 regulation of phosphatidylcholine catabolic process
GO:0015914 phospholipid transport
GO:0015920 lipopolysaccharide transport
GO:0030301 cholesterol transport
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032497 detection of lipopolysaccharide
GO:0033344 cholesterol efflux
GO:0034375 high-density lipoprotein particle remodeling
GO:0034383 low-density lipoprotein particle clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0042632 cholesterol homeostasis
GO:0043534 blood vessel endothelial cell migration
GO:0043654 recognition of apoptotic cell
GO:0043691 reverse cholesterol transport
GO:0044406 adhesion of symbiont to host
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0070328 triglyceride homeostasis
GO:0070508 cholesterol import
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Lipoprotein metabolism pathway
HDL-mediated lipid transport pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Scavenging by Class B Receptors pathway
Lipid digestion, mobilization, and transport pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
HDL-mediated lipid transport pathway
Metabolism pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Metabolism of lipids and lipoproteins pathway
Lipid digestion, mobilization, and transport pathway
Lipoprotein metabolism pathway
Scavenging by Class B Receptors pathway
KEGG
Fat digestion and absorption pathway
Bile secretion pathway
Phagosome pathway
Hepatitis C pathway
Phagosome pathway
Bile secretion pathway
Hepatitis C pathway
Fat digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A4IFC6
UniProt Splice Variant
Entrez Gene 282346
UniGene Bt.4520
RefSeq XM_005217738 NM_174597 XM_005217739
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134513 DAAA02045205 DAAA02045206 DAAA02045207
GenPept AAI34514
RNA Seq Atlas 282346