InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scarb1

Summary

InnateDB Gene

IDBG-201281.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scarb1

Gene Name

scavenger receptor class B, member 1

Synonyms

AI120173; CD36; Cd36l1; Cla-1; Cla1; D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1; SRBI

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037936

Encoded Proteins

IDBP-201283

scavenger receptor class B, member 1

IDBP-258244

scavenger receptor class B, member 1

IDBP-531717

scavenger receptor class B, member 1

IDBP-536421

scavenger receptor class B, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22589557

Scarb1 regulates the macrophage inflammatory response to LPS.

InnateDB Annotation from Orthologs

Summary

PMID 22589557

[Homo sapiens] SCARB1 regulates the macrophage inflammatory response to LPS. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073060:
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:125277087-125341094

Strand

Reverse strand

Band

G1.1

Transcripts

ENSMUST00000086075	ENSMUSP00000083242
ENSMUST00000111390	ENSMUSP00000107021
ENSMUST00000127148	ENSMUSP00000122100
ENSMUST00000124582
ENSMUST00000135736
ENSMUST00000148373
ENSMUST00000123338
ENSMUST00000133624
ENSMUST00000137783	ENSMUSP00000117170
ENSMUST00000156532

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001875	lipopolysaccharide receptor activity
GO:0005515	protein binding
GO:0008035	high-density lipoprotein particle binding
GO:0030169	low-density lipoprotein particle binding
GO:0034185	apolipoprotein binding
GO:0034186	apolipoprotein A-I binding
GO:0042803	protein homodimerization activity
GO:0070506	high-density lipoprotein particle receptor activity

Biological Process

GO:0001935	endothelial cell proliferation
GO:0006702	androgen biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0006869	lipid transport
GO:0006898	receptor-mediated endocytosis
GO:0006910	phagocytosis, recognition
GO:0007155	cell adhesion
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010886	positive regulation of cholesterol storage
GO:0010899	regulation of phosphatidylcholine catabolic process
GO:0015914	phospholipid transport
GO:0015920	lipopolysaccharide transport
GO:0030301	cholesterol transport
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032497	detection of lipopolysaccharide
GO:0033344	cholesterol efflux
GO:0034375	high-density lipoprotein particle remodeling
GO:0034383	low-density lipoprotein particle clearance
GO:0034384	high-density lipoprotein particle clearance
GO:0042632	cholesterol homeostasis
GO:0043534	blood vessel endothelial cell migration
GO:0043654	recognition of apoptotic cell
GO:0043691	reverse cholesterol transport
GO:0044406	adhesion of symbiont to host
GO:0045087	innate immune response (InnateDB)
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0070328	triglyceride homeostasis
GO:0070508	cholesterol import

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031528	microvillus membrane
GO:0070062	extracellular vesicular exosome