Version 5.4
| Bos taurus Gene: VEGFA | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Gene | IDBG-631915.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | VEGFA | ||||||||
| Gene Name | Vascular endothelial growth factor A | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000005339 | ||||||||
| Encoded Proteins |
vascular endothelial growth factor A
vascular endothelial growth factor A
vascular endothelial growth factor A
vascular endothelial growth factor A
|
||||||||
| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] VEGFA-induced tissue response, e.g. angiogenesis, is inhibited during RSV and Influenza viral infections. These effects were mediated by RIG-I and IFNR-dependent pathways, and consequently inhibited the Th2 inflammation response.
[Mus musculus] Vegfa-induced tissue response, e.g. angiogenesis, is inhibited during RSV and Influenza viral infections. These effects were mediated by RIG-I and IFNR-dependent pathways, and consequently inhibited the Th2 inflammation response.
|
||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112715:
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008] |
||||||||
| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 23:17255947-17269998 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
|
||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Orthologs | |||||||||
|
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
VEGF binds to VEGFR leading to receptor dimerization pathway
VEGF ligand-receptor interactions pathway
Regulation of gene expression by Hypoxia-inducible Factor pathway
Cellular responses to stress pathway
Signaling by VEGF pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Cellular response to hypoxia pathway
Hemostasis pathway
Platelet degranulation pathway
Hemostasis pathway
VEGF ligand-receptor interactions pathway
Cellular responses to stress pathway
Signaling by VEGF pathway
Cellular response to hypoxia pathway
EPHA-mediated growth cone collapse pathway
VEGFR2 mediated cell proliferation pathway
Platelet activation, signaling and aggregation pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Regulation of gene expression by Hypoxia-inducible Factor pathway
EPH-Ephrin signaling pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Developmental Biology pathway
VEGF binds to VEGFR leading to receptor dimerization pathway
Response to elevated platelet cytosolic Ca2+ pathway
Signal Transduction pathway
|
||||||||
| KEGG |
mTOR signaling pathway pathway
VEGF signaling pathway pathway
Renal cell carcinoma pathway
Bladder cancer pathway
Cytokine-cytokine receptor interaction pathway
Focal adhesion pathway
Pancreatic cancer pathway
Pathways in cancer pathway
Cytokine-cytokine receptor interaction pathway
Bladder cancer pathway
Renal cell carcinoma pathway
VEGF signaling pathway pathway
mTOR signaling pathway pathway
Focal adhesion pathway
Pancreatic cancer pathway
Pathways in cancer pathway
|
||||||||
| INOH |
VEGF signaling pathway pathway
GPCR signaling pathway
VEGF signaling pathway pathway
GPCR signaling pathway
|
||||||||
| PID NCI |
VEGF and VEGFR signaling network
Beta1 integrin cell surface interactions
S1P1 pathway
Integrins in angiogenesis
Glypican 1 network
Alpha9 beta1 integrin signaling events
Plexin-D1 Signaling
HIF-2-alpha transcription factor network
Signaling events mediated by TCPTP
S1P3 pathway
Signaling events mediated by VEGFR1 and VEGFR2
HIF-1-alpha transcription factor network
SHP2 signaling
Beta3 integrin cell surface interactions
VEGFR1 specific signals
|
||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Bt.71502 | ||||||||
| RefSeq | |||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||