Version 5.4
Bos taurus Gene: PRDM1
Summary
InnateDB Gene IDBG-631919.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDM1
Gene Name PR domain zinc finger protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000816
Encoded Proteins
IDBP-683493
PR domain containing 1, with ZNF domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24477914
[Mus musculus] Prdm1 (Blimp1) modulates host defences by suppressing Ccl8-induced inflammation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057657:
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:44355220-44377512
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001081 ENSBTAP00000001081
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001892 embryonic placenta development
GO:0001893 maternal placenta development
GO:0007281 germ cell development
GO:0009791 post-embryonic development
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0030889 negative regulation of B cell proliferation
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0042462 eye photoreceptor cell development
GO:0045165 cell fate commitment
GO:0045579 positive regulation of B cell differentiation
GO:0060576 intestinal epithelial cell development
GO:0060707 trophoblast giant cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000057657
View Gene Order
ENSMUSG00000038151
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.42074
RefSeq NM_001192936 XM_005210834 XM_005210835 XM_005210836
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca