InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: USP2

Summary

InnateDB Gene

IDBG-631946.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP2

Gene Name

Ubiquitin carboxyl-terminal hydrolase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009749

Encoded Proteins

IDBP-683536

Ubiquitin carboxyl-terminal hydrolase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25070846

[Homo sapiens] USP2 deubiquitinates K63-linked polyubiquitin chains from TBK1 to terminate TBK1 activation and negatively regulate IFNB1 signalling and antiviral immune response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000036672:
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:30464926-30487308

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000012857

ENSBTAP00000012857

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0030332	cyclin binding
GO:0031625	ubiquitin protein ligase binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0007517	muscle organ development
GO:0016579	protein deubiquitination
GO:0045931	positive regulation of mitotic cell cycle
GO:0050821	protein stabilization

Cellular Component

GO:0005737	cytoplasm
GO:0005938	cell cortex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000036672

View Gene Order

ENSMUSG00000032010

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.21721

RefSeq

NM_001046263 XM_005215967

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas