InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Usp2

Summary

InnateDB Gene

IDBG-155467.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp2

Gene Name

ubiquitin specific peptidase 2

Synonyms

B930035K21Rik; Ubp41

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032010

Encoded Proteins

IDBP-155469

ubiquitin specific peptidase 2

IDBP-155471

ubiquitin specific peptidase 2

IDBP-250927

ubiquitin specific peptidase 2

IDBP-741973

IDBP-742072

IDBP-742604

IDBP-741756

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25070846

[Homo sapiens] USP2 deubiquitinates K63-linked polyubiquitin chains from TBK1 to terminate TBK1 activation and negatively regulate IFNB1 signalling and antiviral immune response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000036672:
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:44067021-44095627

Strand

Forward strand

Band

A5.1

Transcripts

ENSMUST00000034508	ENSMUSP00000034508
ENSMUST00000065461	ENSMUSP00000070264
ENSMUST00000114830	ENSMUSP00000110479
ENSMUST00000176671	ENSMUSP00000135859
ENSMUST00000176416	ENSMUSP00000135482
ENSMUST00000177422
ENSMUST00000176022
ENSMUST00000175816	ENSMUSP00000135788
ENSMUST00000177054	ENSMUSP00000135018

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0030332	cyclin binding
GO:0031625	ubiquitin protein ligase binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0007517	muscle organ development
GO:0016579	protein deubiquitination
GO:0045931	positive regulation of mitotic cell cycle
GO:0048642	negative regulation of skeletal muscle tissue development
GO:0048643	positive regulation of skeletal muscle tissue development
GO:0050821	protein stabilization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005938	cell cortex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000036672

View Gene Order

ENSBTAG00000009749

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.272770 Mm.420660

RefSeq

NM_016808 NM_198091 NM_198092 XM_006510480 XM_006510481 XM_006510482 XM_006510483

OMIM

CCDS

CCDS23094 CCDS23095

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas