InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP6V0A2

Summary

InnateDB Gene

IDBG-632091.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0A2

Gene Name

V-type proton ATPase 116 kDa subunit a isoform 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007272

Encoded Proteins

IDBP-683694

V-type proton ATPase 116 kDa subunit a isoform 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185344:
The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:54201717-54241005

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000009563

ENSBTAP00000009563

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport

Cellular Component

GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain
GO:0001669	acrosomal vesicle
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain