Bos taurus Gene: GTF2H3
Summary
InnateDB Gene IDBG-632172.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTF2H3
Gene Name ral transcription factor IIH subunit 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007270
Encoded Proteins
ral transcription factor IIH subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111358:
This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:54276968-54293683
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009561 ENSBTAP00000009561
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0008094 DNA-dependent ATPase activity
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
Cellular Component
GO:0000439 core TFIIH complex
GO:0005634 nucleus
GO:0005675 holo TFIIH complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
RNA Polymerase I Transcription Termination pathway
RNA Polymerase II Transcription pathway
mRNA Capping pathway
Transcription-coupled NER (TC-NER) pathway
RNA Polymerase II Pre-transcription Events pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
RNA Polymerase II Promoter Escape pathway
RNA Polymerase I Promoter Escape pathway
RNA Polymerase I Transcription pathway
Gene Expression pathway
Nucleotide Excision Repair pathway
Global Genomic NER (GG-NER) pathway
RNA Polymerase I Chain Elongation pathway
Dual incision reaction in GG-NER pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
RNA Polymerase II Transcription Elongation pathway
DNA Repair pathway
Dual incision reaction in TC-NER pathway
Formation of RNA Pol II elongation complex pathway
Formation of incision complex in GG-NER pathway
RNA Polymerase I Transcription Initiation pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
RNA Polymerase II Transcription Initiation pathway
RNA Polymerase I Promoter Clearance pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
REACTOME
RNA Polymerase I Transcription Termination pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Promoter Escape pathway
RNA Polymerase I Transcription Initiation pathway
mRNA Capping pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase II Pre-transcription Events pathway
Formation of RNA Pol II elongation complex pathway
Formation of the Early Elongation Complex pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Promoter Escape pathway
RNA Polymerase II Transcription Initiation pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
HIV Transcription Initiation pathway
RNA Polymerase II HIV Promoter Escape pathway
Formation of the HIV-1 Early Elongation Complex pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Transcription of the HIV genome pathway
Late Phase of HIV Life Cycle pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
Dual incision reaction in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Dual incision reaction in GG-NER pathway
Formation of incision complex in GG-NER pathway
RNA Polymerase I Transcription pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Global Genomic NER (GG-NER) pathway
HIV Transcription Elongation pathway
RNA Polymerase II Transcription pathway
HIV Life Cycle pathway
HIV Infection pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Nucleotide Excision Repair pathway
Gene Expression pathway
Disease pathway
DNA Repair pathway
Negative epigenetic regulation of rRNA expression pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
Transcription-coupled NER (TC-NER) pathway
RNA Polymerase I Transcription pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Formation of the Early Elongation Complex pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
Dual incision reaction in GG-NER pathway
RNA Polymerase II Transcription Initiation pathway
RNA Polymerase II Promoter Escape pathway
Global Genomic NER (GG-NER) pathway
Formation of incision complex in GG-NER pathway
RNA Polymerase I Transcription Termination pathway
Nucleotide Excision Repair pathway
Formation of RNA Pol II elongation complex pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
DNA Repair pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Pre-transcription Events pathway
mRNA Capping pathway
Gene Expression pathway
RNA Polymerase I Promoter Escape pathway
Dual incision reaction in TC-NER pathway
RNA Polymerase I Promoter Clearance pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase II Transcription pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
RNA Polymerase I Transcription Initiation pathway
KEGG
Basal transcription factors pathway
Nucleotide excision repair pathway
Basal transcription factors pathway
Nucleotide excision repair pathway
INOH
PID NCI
Cross-References
SwissProt Q05B56
TrEMBL G3X6N2
UniProt Splice Variant
Entrez Gene 511896
UniGene Bt.103768
RefSeq NM_001079589 XM_005217803 XM_005217804
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122792 DAAA02045235
GenPept AAI22793
RNA Seq Atlas 511896