Version 5.4
| Bos taurus Gene: NFKBIE | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-632192.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | NFKBIE | ||||||
| Gene Name | NF-kappa-B inhibitor epsilon | ||||||
| Synonyms | |||||||
| Species | Bos taurus | ||||||
| Ensembl Gene | ENSBTAG00000013705 | ||||||
| Encoded Proteins |
NF-kappa-B inhibitor epsilon
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| InnateDB Annotation from Orthologs | |||||||
| Summary |
[Homo sapiens] NFKBIE is part of the IkappaB family of proteins that regulates NF-kappaB-dependent transcription by inhibiting DNA binding and localizing these factors to the cell cytoplasm, specifically by sequestering REL and RELA in the cytoplasm and inhibiting nuclear export.
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| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146232:
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 23:17879935-17887291 | ||||||
| Strand | Reverse strand | ||||||
| Band | |||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH |
TNFalpha pathway
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| REACTOME |
Activation of NF-kappaB in B cells pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Signaling by the B Cell Receptor (BCR) pathway
Immune System pathway
Activation of NF-kappaB in B cells pathway
Adaptive Immune System pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
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| KEGG |
B cell receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Adipocytokine signaling pathway pathway
Neurotrophin signaling pathway pathway
T cell receptor signaling pathway pathway
Adipocytokine signaling pathway pathway
B cell receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
B cell receptor signaling pathway
TNFR1 signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
B cell receptor signaling pathway
TNFR1 signaling pathway pathway
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| PID NCI | |||||||
| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | F1MVS1 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 506727 | ||||||
| UniGene | Bt.1536 | ||||||
| RefSeq | NM_001130746 | ||||||
| HUGO | |||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | DAAA02055127 | ||||||
| GenPept | |||||||
| RNA Seq Atlas | 506727 | ||||||