Version 5.4
Homo sapiens Gene: NFKBIE
Summary
InnateDB Gene IDBG-89543.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFKBIE
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Synonyms IKBE
Species Homo sapiens
Ensembl Gene ENSG00000146232
Encoded Proteins
IDBP-89545
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
IDBP-380559
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
IDBP-718638
IDBP-810699
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
IDBP-810706
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 11152669
NFKBIE is part of the IkappaB family of proteins that regulates NF-kappaB-dependent transcription by inhibiting DNA binding and localizing these factors to the cell cytoplasm, specifically by sequestering REL and RELA in the cytoplasm and inhibiting nuclear export.
Entrez Gene
Summary The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:44258166-44265788
Strand Reverse strand
Band p21.1
Transcripts
ENST00000275015 ENSP00000275015
ENST00000443607 ENSP00000394658
ENST00000477930 ENSP00000454778
ENST00000619360 ENSP00000480216
ENST00000616555 ENSP00000479764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 31 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0042942 D-serine transport
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023947
View Gene Order
ENSBTAG00000013705
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_118656
Activation of NF-kappaB in B cells pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
B cell receptor signaling pathway
INOH website
TNFR1 signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004556
HUGO
OMIM
CCDS CCDS34463
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca