InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TNFRSF1B

Summary

InnateDB Gene

IDBG-632369.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF1B

Gene Name

tumor necrosis factor receptor superfamily member 1B precursor

Synonyms

TNF-RII/TNFRSF1B

Species

Bos taurus

Ensembl Gene

ENSBTAG00000024928

Encoded Proteins

IDBP-683975

tumor necrosis factor receptor superfamily member 1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 17220297

[Homo sapiens] TNFRSF1B signalling induces selective BIRC2-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000028137:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:42376258-42409768

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000034729

ENSBTAP00000034614

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0050728	negative regulation of inflammatory response
GO:0050779	RNA destabilization
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0071222	cellular response to lipopolysaccharide
GO:0097191	extrinsic apoptotic signaling pathway