Version 5.4
Mus musculus Gene: Tnfrsf1b
Summary
InnateDB Gene IDBG-203277.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfrsf1b
Gene Name tumor necrosis factor receptor superfamily, member 1b
Synonyms CD120b; p75; TNF-alphaR2; TNF-R-II; TNF-R2; TNF-R75; TNFalpha-R2; TNFBR; Tnfr-1; Tnfr2; TNFR80; TNFRII
Species Mus musculus
Ensembl Gene ENSMUSG00000028599
Encoded Proteins
IDBP-203279
tumor necrosis factor receptor superfamily, member 1b
IDBP-542830
tumor necrosis factor receptor superfamily, member 1b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 17220297
[Homo sapiens] TNFRSF1B signalling induces selective BIRC2-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000028137:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:145213463-145246870
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000030336 ENSMUSP00000030336
ENSMUST00000143055 ENSMUSP00000115702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 106 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 106 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007568 aging
GO:0008283 cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032496 response to lipopolysaccharide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050779 RNA destabilization
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0071222 cellular response to lipopolysaccharide
GO:0071363 cellular response to growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043025 neuronal cell body
GO:0043196 varicosity
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000028137
View Gene Order
ENSBTAG00000024928
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID NCI
tnfpathway
TNF receptor signaling pathway
Cross-References
SwissProt
TrEMBL D6RG55
UniProt Splice Variant
Entrez Gene 21938
UniGene Mm.466144
RefSeq NM_011610
OMIM
CCDS CCDS18914
HPRD
IMGT
MGI ID MGI:1314883
MGI Symbol Tnfrsf1b
EMBL AL627099 AL731675
GenPept
RNA Seq Atlas 21938

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca