Version 5.4
Bos taurus Gene: NUBPL
Summary
InnateDB Gene IDBG-632387.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUBPL
Gene Name iron-sulfur protein NUBPL
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000044121
Encoded Proteins
IDBP-683994
nucleotide binding protein-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151413:
This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. The respiratory complex I consists of 45 subunits and 8 iron-sulfur (Fe/S) clusters. This protein is an Fe/S protein that plays a critical role in the assembly of respiratory complex I, likely by transferring Fe/S into the Fe/S-containing complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding distinct isoforms have been identified.[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:42475716-42719201
Strand Forward strand
Band
Transcripts
ENSBTAT00000061529 ENSBTAP00000053647
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0070584 mitochondrion morphogenesis
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000151413
View Gene Order
ENSMUSG00000035142
View Gene Order
Cross-References
SwissProt
TrEMBL E1BE32
UniProt Splice Variant
Entrez Gene 614641
UniGene Bt.63067
RefSeq NM_001193042
HUGO HGNC:20278
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02052675 DAAA02052676 DAAA02052677 DAAA02052678 DAAA02052679 DAAA02052680 DAAA02052681
GenPept
RNA Seq Atlas 614641
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca