Version 5.4
Homo sapiens Gene: NUBPL
Summary
InnateDB Gene IDBG-4421.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUBPL
Gene Name nucleotide binding protein-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151413
Encoded Proteins
IDBP-4423
nucleotide binding protein-like
IDBP-594400
nucleotide binding protein-like
IDBP-584438
nucleotide binding protein-like
IDBP-584245
nucleotide binding protein-like
IDBP-600754
nucleotide binding protein-like
IDBP-603112
nucleotide binding protein-like
IDBP-602478
nucleotide binding protein-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. The respiratory complex I consists of 45 subunits and 8 iron-sulfur (Fe/S) clusters. This protein is an Fe/S protein that plays a critical role in the assembly of respiratory complex I, likely by transferring Fe/S into the Fe/S-containing complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding distinct isoforms have been identified.[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:31489956-31861224
Strand Forward strand
Band q12
Transcripts
ENST00000281081 ENSP00000281081
ENST00000418681
ENST00000550005 ENSP00000446511
ENST00000552814
ENST00000550649 ENSP00000447618
ENST00000547839 ENSP00000449918
ENST00000548937
ENST00000552489 ENSP00000447316
ENST00000549838 ENSP00000447658
ENST00000550355
ENST00000551314 ENSP00000447234
ENST00000551015
ENST00000552888
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0070584 mitochondrion morphogenesis
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035142
View Gene Order
ENSBTAG00000044121
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.288981 Hs.734993
RefSeq NM_001201573 NM_001201574 NM_025152 XM_005268099
HUGO
OMIM
CCDS CCDS41940
HPRD 16600
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca