Version 5.4
Bos taurus Gene: CD2AP
Summary
InnateDB Gene IDBG-632396.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD2AP
Gene Name CD2-associated protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000322
Encoded Proteins
IDBP-684036
CD2-associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198087:
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:20596998-20680179
Strand Forward strand
Band
Transcripts
ENSBTAT00000061046 ENSBTAP00000053206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0032911 negative regulation of transforming growth factor beta1 production
GO:1900182 positive regulation of protein localization to nucleus
GO:2000249 regulation of actin cytoskeleton reorganization
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0031941 filamentous actin
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000198087
View Gene Order
ENSMUSG00000061665
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_23832
Nephrin interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_257032
Nephrin interactions pathway
REACT_223082
Cell-Cell communication pathway
KEGG
hsa05100
Bacterial invasion of epithelial cells pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
vegfr1_pathway
VEGFR1 specific signals
Cross-References
SwissProt
TrEMBL F1MM14
UniProt Splice Variant
Entrez Gene 533188
UniGene Bt.2052
RefSeq NM_001206539
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02055183
GenPept
RNA Seq Atlas 533188

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca