InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cd2ap

Summary

InnateDB Gene

IDBG-183950.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd2ap

Gene Name

CD2-associated protein

Synonyms

AL024079; C78928; METS-1; Mets1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061665

Encoded Proteins

IDBP-183952

CD2-associated protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. The mouse genome contains at least two pseudogenes located on chromosomes 9 and 17. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:42792951-42876424

Strand

Reverse strand

Band

Transcripts

ENSMUST00000024709

ENSMUSP00000024709

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005172	vascular endothelial growth factor receptor binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0017124	SH3 domain binding
GO:0032403	protein complex binding
GO:0045296	cadherin binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0016050	vesicle organization
GO:0016337	single organismal cell-cell adhesion
GO:0016477	cell migration
GO:0032911	negative regulation of transforming growth factor beta1 production
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048259	regulation of receptor-mediated endocytosis
GO:1900182	positive regulation of protein localization to nucleus
GO:2000249	regulation of actin cytoskeleton reorganization

Cellular Component

GO:0001726	ruffle
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005938	cell cortex
GO:0030139	endocytic vesicle
GO:0031941	filamentous actin
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000198087

View Gene Order

ENSBTAG00000000322

Not yet available

Pathways

NETPATH

REACTOME

REACT_257032

Nephrin interactions pathway

REACT_223082

Cell-Cell communication pathway

KEGG

mmu05100

Bacterial invasion of epithelial cells pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

REACT_23832

Nephrin interactions pathway

REACT_111155

Cell-Cell communication pathway

KEGG

hsa05100

Bacterial invasion of epithelial cells pathway

INOH

PID NCI

nephrin_neph1_pathway

Nephrin/Neph1 signaling in the kidney podocyte

vegfr1_pathway

VEGFR1 specific signals

Cross-References

SwissProt

Q9JLQ0

TrEMBL

UniProt Splice Variant

Entrez Gene

12488

UniGene

Mm.218637 Mm.402596 Mm.460981

RefSeq

NM_009847

OMIM

CCDS

CCDS50114

HPRD

IMGT

MGI ID

MGI:1330281

MGI Symbol

Cd2ap

EMBL

AC111082 AF077003 AF149092 AJ459109 BC019744

GenPept

AAC36099 AAF73150 AAH19744 CAD30510

RNA Seq Atlas

12488