InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GPD1

Summary

InnateDB Gene

IDBG-632413.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPD1

Gene Name

Glycerol-3-phosphate dehydrogenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016296

Encoded Proteins

IDBP-684022

Glycerol-3-phosphate dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167588:
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:29958501-29964085

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000021683

ENSBTAP00000021683

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0004368	glycerol-3-phosphate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity
GO:0050662	coenzyme binding
GO:0051287	NAD binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006072	glycerol-3-phosphate metabolic process
GO:0006094	gluconeogenesis
GO:0006127	glycerophosphate shuttle
GO:0045821	positive regulation of glycolytic process
GO:0046168	glycerol-3-phosphate catabolic process
GO:0055114	oxidation-reduction process
GO:0071320	cellular response to cAMP
GO:0071356	cellular response to tumor necrosis factor

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0009331	glycerol-3-phosphate dehydrogenase complex
GO:0070062	extracellular vesicular exosome