InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FOLR1

Summary

InnateDB Gene

IDBG-63244.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOLR1

Gene Name

folate receptor 1 (adult)

Synonyms

FBP; FOLR

Species

Homo sapiens

Ensembl Gene

ENSG00000110195

Encoded Proteins

IDBP-63246

folate receptor 1 (adult)

IDBP-243129

folate receptor 1 (adult)

IDBP-243131

folate receptor 1 (adult)

IDBP-243133

folate receptor 1 (adult)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:72189558-72196301

Strand

Forward strand

Band

q13.4

Transcripts

ENST00000312293	ENSP00000308137
ENST00000393681	ENSP00000377286
ENST00000393679	ENSP00000377284
ENST00000393676	ENSP00000377281

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005542	folic acid binding
GO:0008517	folic acid transporter activity

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0008219	cell death
GO:0015884	folic acid transport
GO:0046655	folic acid metabolic process

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030136	clathrin-coated vesicle
GO:0031362	anchored component of external side of plasma membrane
GO:0031526	brush border membrane
GO:0046658	anchored component of plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001827

View Gene Order

ENSBTAG00000038532

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

P15328

TrEMBL

A0A024R5H1 Q6LDL1 Q96QD1 Q9NP04

UniProt Splice Variant

Entrez Gene

2348

UniGene

Hs.600451 Hs.73769

RefSeq

NM_000802 NM_016724 NM_016725 NM_016729

HUGO

HGNC:3791

OMIM

136430

CCDS

CCDS8211

HPRD

00638

IMGT

EMBL

AK223527 BC002947 BT007158 CH471076 CR542019 J05013 M25317 M28099 M35069 S73474 S73490 U20391 U78793 U78794 X62753

GenPept

AAA35822 AAA35823 AAA35824 AAA74896 AAB05827 AAB31700 AAB31702 AAB39751 AAB39752 AAH02947 AAP35822 BAD97247 CAA44610 CAG46816 EAW74848 EAW74850 EAW74851 EAW74852

RNA Seq Atlas

2348