Version 5.4
Bos taurus Gene: FOLR1
Summary
InnateDB Gene IDBG-635044.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOLR1
Gene Name folate receptor 1 (adult)-like precursor
Synonyms FBP; FR-alpha
Species Bos taurus
Ensembl Gene ENSBTAG00000038532
Encoded Proteins
IDBP-686839
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110195:
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:52563234-52567329
Strand Forward strand
Band
Transcripts
ENSBTAT00000027602 ENSBTAP00000027602
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005542 folic acid binding
GO:0008517 folic acid transporter activity
Biological Process
GO:0006810 transport
GO:0015884 folic acid transport
Cellular Component
GO:0005576 extracellular region
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016324 apical plasma membrane
GO:0030136 clathrin-coated vesicle
GO:0031225 anchored component of membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000110195
View Gene Order
ENSMUSG00000001827
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt P02702
TrEMBL
UniProt Splice Variant
Entrez Gene 516067
UniGene
RefSeq NM_001206527 NM_001206530 NM_001278572 NM_001278573
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DN512948
GenPept
RNA Seq Atlas 516067

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca