InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HCFC1

Summary

InnateDB Gene

IDBG-632542.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCFC1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011904

Encoded Proteins

IDBP-684188

host cell factor C1 (VP16-accessory protein)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172534:
This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:40075766-40095591

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015793

ENSBTAP00000015793

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043995	histone acetyltransferase activity (H4-K5 specific)
GO:0043996	histone acetyltransferase activity (H4-K8 specific)
GO:0046972	histone acetyltransferase activity (H4-K16 specific)

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0010628	positive regulation of gene expression
GO:0019046	release from viral latency
GO:0043254	regulation of protein complex assembly
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043984	histone H4-K16 acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050821	protein stabilization

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005634	nucleus
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0043025	neuronal cell body
GO:0048188	Set1C/COMPASS complex
GO:0070461	SAGA-type complex
GO:0070688	MLL5-L complex
GO:0071339	MLL1 complex