Version 5.4
Homo sapiens Gene: HCFC1
Summary
InnateDB Gene IDBG-90667.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCFC1
Gene Name host cell factor C1 (VP16-accessory protein)
Synonyms CFF; HCF-1; HCF1; HFC1; MRX3; PPP1R89; VCAF
Species Homo sapiens
Ensembl Gene ENSG00000172534
Encoded Proteins
IDBP-90671
host cell factor C1 (VP16-accessory protein)
IDBP-90673
host cell factor C1 (VP16-accessory protein)
IDBP-383232
host cell factor C1 (VP16-accessory protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153947553-153971807
Strand Reverse strand
Band q28
Transcripts
ENST00000369984 ENSP00000359001
ENST00000310441 ENSP00000309555
ENST00000444191 ENSP00000399589
ENST00000461098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 133 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 133 [view]
Protein-Protein 129 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007049 cell cycle
GO:0010628 positive regulation of gene expression
GO:0019046 release from viral latency
GO:0043254 regulation of protein complex assembly
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
GO:0045787 positive regulation of cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050821 protein stabilization
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0043025 neuronal cell body
GO:0048188 Set1C/COMPASS complex
GO:0070461 SAGA-type complex
GO:0070688 MLL5-L complex
GO:0071339 MLL1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031386
View Gene Order
ENSBTAG00000011904
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P51610
TrEMBL Q05C05
UniProt Splice Variant
Entrez Gene 3054
UniGene Hs.83634
RefSeq NM_005334 XM_005274664 XM_006724815 XM_006724816
HUGO HGNC:4839
OMIM 300019
CCDS CCDS44020
HPRD 02061
IMGT
EMBL BC019887 BC030560 BC063435 L20010 U52112 X79198
GenPept AAH19887 AAH30560 AAH63435 CAA55790
RNA Seq Atlas 3054

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca