InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CFTR

Summary

InnateDB Gene

IDBG-632747.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFTR

Gene Name

cystic fibrosis transmembrane conductance regulator

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006589

Encoded Proteins

IDBP-684415

cystic fibrosis transmembrane conductance regulator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21712022

[Homo sapiens] CFTR deficiency alters the innate immunity of the biliary epithelium and reduces endotoxin tolerance, resulting in increased inflammatory response mediated by TLR4 and NFkB.

PMID 22859830

[Homo sapiens] CFTR is involved in myeloid cell function and its absence from myeloid-derived cells slows resolution of inflammation and infection of the lung. (Demonstrated in mouse)

PMID 21712022

[Mus musculus] Cftr deficiency alters the innate immunity of the biliary epithelium and reduces endotoxin tolerance, resulting in increased inflammatory response mediated by Tlr4 and NFkB.

PMID 22859830

[Mus musculus] Cftr is involved in myeloid cell function and its absence from myeloid-derived cells slows resolution of inflammation and infection of the lung.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000001626:
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:51035771-51249563

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000053450

ENSBTAP00000049907

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 233 interaction(s) predicted by orthology.

Predicted by orthology
Total	233 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005254	chloride channel activity
GO:0005260	channel-conductance-controlling ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0019869	chloride channel inhibitor activity
GO:0019899	enzyme binding
GO:0030165	PDZ domain binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006695	cholesterol biosynthetic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0030301	cholesterol transport
GO:0048240	sperm capacitation
GO:0051454	intracellular pH elevation
GO:0055085	transmembrane transport
GO:0060081	membrane hyperpolarization
GO:0071320	cellular response to cAMP
GO:1902476	chloride transmembrane transport
GO:1902943	positive regulation of voltage-gated chloride channel activity

Cellular Component

GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031205	endoplasmic reticulum Sec complex
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome