InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PRPF8

Summary

InnateDB Gene

IDBG-632840.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRPF8

Gene Name

pre-mRNA-processing-splicing factor 8

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011488

Encoded Proteins

IDBP-684534

pre-mRNA-processing-splicing factor 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174231:
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:23324762-23357323

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000046260

ENSBTAP00000043577

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.

Predicted by orthology
Total	107 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0017070	U6 snRNA binding
GO:0030623	U5 snRNA binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity