Version 5.4
Bos taurus Gene: S100A12
Summary
InnateDB Gene IDBG-632871.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100A12
Gene Name Protein S100-A12
Synonyms CAAF1; CAGC; CO-AG; EN-RAGE
Species Bos taurus
Ensembl Gene ENSBTAG00000012638
Encoded Proteins
IDBP-684541
Protein S100-A12
IDBP-684545
Protein S100-A12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:17163820-17165262
Strand Forward strand
Band
Transcripts
ENSBTAT00000063314 ENSBTAP00000056088
ENSBTAT00000034108 ENSBTAP00000034009
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008144 drug binding
GO:0046872 metal ion binding
GO:0050786 RAGE receptor binding
Biological Process
GO:0002376 immune system process
GO:0006805 xenobiotic metabolic process
GO:0006954 inflammatory response
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043303 mast cell degranulation
GO:0045087 innate immune response
GO:0050832 defense response to fungus
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042629 mast cell granule
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_224546
MyD88-independent cascade pathway
REACT_220974
Cytosolic sensors of pathogen-associated DNA pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_221101
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_218118
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_213138
Immune System pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_207058
TRAF6 mediated NF-kB activation pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_204725
Advanced glycosylation endproduct receptor signaling pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_217214
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_216714
Innate Immune System pathway
REACT_209403
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_215391
RIP-mediated NFkB activation via ZBP1 pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.357
RefSeq NM_174651 XM_005203615
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca