Version 5.4
Bos taurus Gene: RPA1
Summary
InnateDB Gene IDBG-632940.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPA1
Gene Name replication protein A 70 kDa DNA-binding subunit
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009711
Encoded Proteins
IDBP-684620
replication protein A 70 kDa DNA-binding subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132383:
Gene Information
Type Protein coding
Genomic Location Chromosome 19:23476634-23527009
Strand Forward strand
Band
Transcripts
ENSBTAT00000012812 ENSBTAP00000012812
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 105 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
Biological Process
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0001701 in utero embryonic development
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
GO:0006298 mismatch repair
GO:0006310 DNA recombination
GO:0007126 meiotic nuclear division
GO:0008284 positive regulation of cell proliferation
GO:0030097 hemopoiesis
GO:0048873 homeostasis of number of cells within a tissue
GO:0051276 chromosome organization
Cellular Component
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000800 lateral element
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
GO:0005662 DNA replication factor A complex
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000132383
View Gene Order
ENSMUSG00000000751
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_7999
Removal of the Flap Intermediate from the C-strand pathway
REACT_8027
Processive synthesis on the C-strand of the telomere pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_70
Removal of the Flap Intermediate pathway
REACT_1385
Processive synthesis on the lagging strand pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1993
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_311
Dual incision reaction in GG-NER pathway
REACT_257
Formation of incision complex in GG-NER pathway
REACT_378
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_2055
Processing of DNA double-strand break ends pathway
REACT_2141
Assembly of the RAD51-ssDNA nucleoprotein complex pathway
REACT_408
Presynaptic phase of homologous DNA pairing and strand exchange pathway
REACT_1763
Homologous DNA pairing and strand exchange pathway
REACT_27271
Meiotic recombination pathway
REACT_383
DNA Replication pathway
REACT_120956
Cellular responses to stress pathway
REACT_2014
Synthesis of DNA pathway
REACT_200780
Regulation of HSF1-mediated heat shock response pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_1783
G1/S Transition pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_115566
Cell Cycle pathway
REACT_228145
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_200819
Cellular response to heat stress pathway
REACT_1725
M/G1 Transition pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_228013
Mismatch Repair pathway
REACT_111183
Meiosis pathway
REACT_200744
HSF1 activation pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_27235
Meiotic Recombination pathway
REACT_262992
Processive synthesis on the lagging strand pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_200794
Mus musculus biological processes pathway
REACT_251075
Removal of the Flap Intermediate pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_202316
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_233453
Chromosome Maintenance pathway
REACT_258062
Synthesis of DNA pathway
REACT_241296
DNA strand elongation pathway
REACT_219381
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_232628
DNA Replication pathway
REACT_240507
Dual incision reaction in GG-NER pathway
REACT_188957
Cellular responses to stress pathway
REACT_238177
Global Genomic NER (GG-NER) pathway
REACT_261855
Assembly of the RAD51-ssDNA nucleoprotein complex pathway
REACT_238355
Double-Strand Break Repair pathway
REACT_237585
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_243723
Homologous DNA pairing and strand exchange pathway
REACT_252672
Telomere Maintenance pathway
REACT_245362
Processing of DNA double-strand break ends pathway
REACT_252106
Formation of incision complex in GG-NER pathway
REACT_188804
Cell Cycle pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_235085
Presynaptic phase of homologous DNA pairing and strand exchange pathway
REACT_216529
Removal of the Flap Intermediate from the C-strand pathway
REACT_209299
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_233397
DNA Repair pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_220175
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_245528
M/G1 Transition pathway
REACT_235397
G2/M Checkpoints pathway
REACT_246095
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_224790
Cellular response to heat stress pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_236124
Mismatch Repair pathway
REACT_252545
Extension of Telomeres pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_223154
Processive synthesis on the C-strand of the telomere pathway
REACT_245263
Lagging Strand Synthesis pathway
REACT_240368
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_222185
Regulation of HSF1-mediated heat shock response pathway
REACT_198624
Meiosis pathway
REACT_198629
Meiotic recombination pathway
REACT_245922
Homologous Recombination Repair pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_253623
S Phase pathway
REACT_251264
Homologous recombination repair of replication-independent double-strand breaks pathway
KEGG
hsa03030
DNA replication pathway
hsa03420
Nucleotide excision repair pathway
hsa03440
Homologous recombination pathway
hsa03430
Mismatch repair pathway
mmu03030
DNA replication pathway
mmu03420
Nucleotide excision repair pathway
mmu03440
Homologous recombination pathway
mmu03430
Mismatch repair pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.19931
RefSeq NM_001075176
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca