InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RPA1

Summary

InnateDB Protein

IDBP-684620.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPA1

Protein Name

replication protein A 70 kDa DNA-binding subunit

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012812

InnateDB Gene

IDBG-632940 (RPA1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	105 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding

Biological Process

GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0001701	in utero embryonic development
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006298	mismatch repair
GO:0006310	DNA recombination
GO:0007126	meiotic nuclear division
GO:0008284	positive regulation of cell proliferation
GO:0030097	hemopoiesis
GO:0048873	homeostasis of number of cells within a tissue
GO:0051276	chromosome organization

Cellular Component

GO:0000793	condensed chromosome
GO:0000794	condensed nuclear chromosome
GO:0000800	lateral element
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005662	DNA replication factor A complex
GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton
GO:0016605	PML body

Protein Structure and Domains

PDB ID

InterPro

IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR004591 Replication factor A protein 1
IPR007199 Replication factor-A protein 1, N-terminal
IPR012340 Nucleic acid-binding, OB-fold
IPR013955 Replication factor A, C-terminal

PFAM

PF01336
PF04057
PF08646

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-