InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KDM2B

Summary

InnateDB Gene

IDBG-632962.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM2B

Gene Name

Uncharacterized protein

Synonyms

FBXL10

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002328

Encoded Proteins

IDBP-684669

lysine (K)-specific demethylase 2B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089094:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:55899388-56017498

Strand

Forward strand

Band

Transcripts

ENSBTAT00000003003

ENSBTAP00000003003

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0021555	midbrain-hindbrain boundary morphogenesis
GO:0021592	fourth ventricle development
GO:0021670	lateral ventricle development
GO:0021678	third ventricle development
GO:0021993	initiation of neural tube closure
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0035518	histone H2A monoubiquitination
GO:0043524	negative regulation of neuron apoptotic process
GO:0048596	embryonic camera-type eye morphogenesis
GO:2000178	negative regulation of neural precursor cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0031519	PcG protein complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000089094

View Gene Order

ENSMUSG00000029475

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_218274

Chromatin organization pathway

REACT_256030

HDMs demethylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.110941

RefSeq

XM_005195036 XM_005195038 XM_005217983 XM_005217985

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas