InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.65227

Summary

InnateDB Gene

IDBG-633035.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.65227

Gene Name

glucose-6-phosphate dehydrogenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019512

Encoded Proteins

IDBP-684739

Glucose-6-phosphate 1-dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160211:
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:40484795-40500923

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025996

ENSBTAP00000025996

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004345	glucose-6-phosphate dehydrogenase activity
GO:0005515	protein binding
GO:0005536	glucose binding
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0050661	NADP binding

Biological Process

GO:0001816	cytokine production
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006098	pentose-phosphate shunt
GO:0006695	cholesterol biosynthetic process
GO:0006739	NADP metabolic process
GO:0006740	NADPH regeneration
GO:0006749	glutathione metabolic process
GO:0009051	pentose-phosphate shunt, oxidative branch
GO:0010734	negative regulation of protein glutathionylation
GO:0019322	pentose biosynthetic process
GO:0021762	substantia nigra development
GO:0034599	cellular response to oxidative stress
GO:0043249	erythrocyte maturation
GO:0046390	ribose phosphate biosynthetic process
GO:0051156	glucose 6-phosphate metabolic process
GO:0055114	oxidation-reduction process