InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: G6pdx

Summary

InnateDB Gene

IDBG-156374.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G6pdx

Gene Name

glucose-6-phosphate dehydrogenase X-linked

Synonyms

G28A; G6pd; Gpdx

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031400

Encoded Proteins

IDBP-156376

glucose-6-phosphate dehydrogenase X-linked

IDBP-542153

glucose-6-phosphate dehydrogenase X-linked

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160211:
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:74409483-74429194

Strand

Reverse strand

Band

A7.3

Transcripts

ENSMUST00000004327	ENSMUSP00000004327
ENSMUST00000143521	ENSMUSP00000115915
ENSMUST00000135894
ENSMUST00000155963

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004345	glucose-6-phosphate dehydrogenase activity
GO:0042803	protein homodimerization activity
GO:0050661	NADP binding

Biological Process

GO:0001816	cytokine production
GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0002033	vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
GO:0006006	glucose metabolic process
GO:0006098	pentose-phosphate shunt
GO:0006739	NADP metabolic process
GO:0006741	NADP biosynthetic process
GO:0006749	glutathione metabolic process
GO:0006979	response to oxidative stress
GO:0019322	pentose biosynthetic process
GO:0032613	interleukin-10 production
GO:0032615	interleukin-12 production
GO:0040014	regulation of multicellular organism growth
GO:0048821	erythrocyte development
GO:0051156	glucose 6-phosphate metabolic process
GO:0055114	oxidation-reduction process