InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.64659

Summary

InnateDB Gene

IDBG-633039.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.64659

Gene Name

cadherin-5 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007421

Encoded Proteins

IDBP-684713

cadherin-5 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179776:
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:34260148-34274741

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009760

ENSBTAP00000009760

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0019903	protein phosphatase binding
GO:0044325	ion channel binding

Biological Process

GO:0001955	blood vessel maturation
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0008285	negative regulation of cell proliferation
GO:2000114	regulation of establishment of cell polarity

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0071944	cell periphery