InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDH5

Summary

InnateDB Gene

IDBG-34871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH5

Gene Name

cadherin 5, type 2 (vascular endothelium)

Synonyms

7B4; CD144

Species

Homo sapiens

Ensembl Gene

ENSG00000179776

Encoded Proteins

IDBP-34873

cadherin 5, type 2 (vascular endothelium)

IDBP-753016

IDBP-751266

IDBP-750992

IDBP-748741

IDBP-747292

IDBP-753155

IDBP-806370

cadherin 5, type 2 (vascular endothelium)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:66366622-66404786

Strand

Forward strand

Band

q21

Transcripts

ENST00000341529	ENSP00000344115
ENST00000539168	ENSP00000461880
ENST00000568155	ENSP00000456093
ENST00000562048	ENSP00000455302
ENST00000563425	ENSP00000458878
ENST00000565334	ENSP00000456028
ENST00000568023	ENSP00000455655
ENST00000614547	ENSP00000479381

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0019903	protein phosphatase binding
GO:0044325	ion channel binding

Biological Process

GO:0001955	blood vessel maturation
GO:0007156	homophilic cell adhesion
GO:0008285	negative regulation of cell proliferation
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0045216	cell-cell junction organization
GO:2000114	regulation of establishment of cell polarity

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0071944	cell periphery