Bos taurus Gene: TK2 | |||||||||
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Summary | |||||||||
InnateDB Gene | IDBG-633052.3 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | TK2 | ||||||||
Gene Name | Uncharacterized protein | ||||||||
Synonyms | |||||||||
Species | Bos taurus | ||||||||
Ensembl Gene | ENSBTAG00000005152 | ||||||||
Encoded Proteins |
thymidine kinase 2, mitochondrial
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Protein Structure | |||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||
Entrez Gene | |||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166548:
This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012] |
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Gene Information | |||||||||
Type | Protein coding | ||||||||
Genomic Location | Chromosome 18:34368485-34393020 | ||||||||
Strand | Reverse strand | ||||||||
Band | |||||||||
Transcripts |
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Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||
NETPATH | |||||||||
REACTOME |
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
Pyrimidine salvage reactions pathway
Metabolism of nucleotides pathway
Mitotic G1-G1/S phases pathway
G1/S Transition pathway
Cell Cycle pathway
Pyrimidine metabolism pathway
Cell Cycle, Mitotic pathway
Metabolism pathway
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KEGG |
Pyrimidine metabolism pathway
Drug metabolism pathway
Pyrimidine metabolism pathway
Drug metabolism pathway
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INOH |
Pyrimidine nucleotides nucleosides metabolism pathway
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PID NCI | |||||||||
Cross-References | |||||||||
SwissProt | |||||||||
TrEMBL | F1MNI9 | ||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 615457 | ||||||||
UniGene | |||||||||
RefSeq | XM_005195237 XM_005195239 XM_005218824 XM_005218826 | ||||||||
HUGO | HGNC:11831 | ||||||||
OMIM | |||||||||
CCDS | |||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | DAAA02046673 | ||||||||
GenPept | |||||||||
RNA Seq Atlas | 615457 | ||||||||