InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tk2

Summary

InnateDB Gene

IDBG-185155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tk2

Gene Name

thymidine kinase 2, mitochondrial

Synonyms

AU024611; mt-TK

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035824

Encoded Proteins

IDBP-185157

thymidine kinase 2, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166548:
This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:104226691-104248558

Strand

Reverse strand

Band

Transcripts

ENSMUST00000050211

ENSMUSP00000053616

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004137	deoxycytidine kinase activity
GO:0004797	thymidine kinase activity
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006264	mitochondrial DNA replication
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
GO:0009262	deoxyribonucleotide metabolic process
GO:0016310	phosphorylation
GO:0032042	mitochondrial DNA metabolic process
GO:0046092	deoxycytidine metabolic process
GO:0046104	thymidine metabolic process