InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.29087

Summary

InnateDB Gene

IDBG-633058.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.29087

Gene Name

ATP-binding cassette sub-family G member 8

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016366

Encoded Proteins

IDBP-684730

ATP-binding cassette sub-family G member 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143921:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:26156648-26174650

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021770

ENSBTAP00000021770

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017127	cholesterol transporter activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007588	excretion
GO:0010949	negative regulation of intestinal phytosterol absorption
GO:0015914	phospholipid transport
GO:0015918	sterol transport
GO:0033344	cholesterol efflux
GO:0042632	cholesterol homeostasis
GO:0045796	negative regulation of intestinal cholesterol absorption
GO:0055092	sterol homeostasis