InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abcg8

Summary

InnateDB Gene

IDBG-200717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcg8

Gene Name

ATP-binding cassette, sub-family G (WHITE), member 8

Synonyms

1300003C16Rik; AI114946; sterolin-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024254

Encoded Proteins

IDBP-200719

ATP-binding cassette, sub-family G (WHITE), member 8

IDBP-621902

ATP-binding cassette, sub-family G (WHITE), member 8

IDBP-621908

ATP-binding cassette, sub-family G (WHITE), member 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143921:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:84676302-84700333

Strand

Forward strand

Band

Transcripts

ENSMUST00000045714	ENSMUSP00000035246
ENSMUST00000170725	ENSMUSP00000127785
ENSMUST00000171915	ENSMUSP00000126675

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015248	sterol transporter activity
GO:0016887	ATPase activity
GO:0017127	cholesterol transporter activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007584	response to nutrient
GO:0007588	excretion
GO:0010949	negative regulation of intestinal phytosterol absorption
GO:0015914	phospholipid transport
GO:0015918	sterol transport
GO:0030299	intestinal cholesterol absorption
GO:0033344	cholesterol efflux
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0045796	negative regulation of intestinal cholesterol absorption
GO:0055092	sterol homeostasis