Version 5.4
| Bos taurus Gene: AGER | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-633065.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | AGER | ||||||||
| Gene Name | advanced glycosylation end product-specific receptor precursor | ||||||||
| Synonyms | RAGE | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000014420 | ||||||||
| Encoded Proteins |
advanced glycosylation end product-specific receptor precursor
advanced glycosylation end product-specific receptor precursor
advanced glycosylation end product-specific receptor precursor
advanced glycosylation end product-specific receptor precursor
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] AGER is a native receptor for complement component C1QA.
[Mus musculus] Ager is a native receptor for complement component C1qa. (Demonstrated in human)
[Mus musculus] S100a8/S100a9 are proinflammatory proteins that activate natural killer cells via Ager signalling.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204305:
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011] The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer\'s disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 23:27008831-27011946 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
RIP-mediated NFkB activation via ZBP1 pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Advanced glycosylation endproduct receptor signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI |
amb2 Integrin signaling
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | F1ABN6 F1N306 G3MZD3 G3N2L6 G3N301 Q3KUS3 Q6SA77 Q6SA78 Q6SA79 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 280986 | ||||||||
| UniGene | Bt.103300 | ||||||||
| RefSeq | NM_173982 XM_005223597 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AY461428 AY461429 AY461430 AY881699 DAAA02055357 GU139385 | ||||||||
| GenPept | AAR23819 AAR23820 AAR23821 AAY57799 ADQ42263 | ||||||||
| RNA Seq Atlas | 280986 | ||||||||