Version 5.4
Bos taurus Gene: DFFA
Summary
InnateDB Gene IDBG-633121.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DFFA
Gene Name DNA fragmentation factor subunit alpha
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013535
Encoded Proteins
IDBP-684806
DNA fragmentation factor subunit alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160049:
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:43994268-44004665
Strand Forward strand
Band
Transcripts
ENSBTAT00000017999 ENSBTAP00000017999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
GO:1900118 negative regulation of execution phase of apoptosis
Cellular Component
GO:0000790 nuclear chromatin
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000160049
View Gene Order
ENSMUSG00000028974
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13462
Activation of DNA fragmentation factor pathway
REACT_995
Apoptotic execution phase pathway
REACT_1213
Apoptosis induced DNA fragmentation pathway
REACT_578
Apoptosis pathway
REACT_258521
Apoptosis pathway
REACT_215449
Apoptosis induced DNA fragmentation pathway
REACT_205002
Activation of DNA fragmentation factor pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
hsa04210
Apoptosis pathway
mmu04210
Apoptosis pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.10997
RefSeq NM_001075342
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca