Version 5.4
Bos taurus Gene: PRKAB1
Summary
InnateDB Gene IDBG-633372.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKAB1
Gene Name 5'-AMP-activated protein kinase subunit beta-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005940
Encoded Proteins
IDBP-685073
5'-AMP-activated protein kinase subunit beta-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111725:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:57999616-58009037
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007798 ENSBTAP00000007798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 156 interaction(s) predicted by orthology.
Predicted by orthology
Total 156 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0016301 kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0010628 positive regulation of gene expression
GO:0016310 phosphorylation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111725
View Gene Order
ENSMUSG00000029513
View Gene Order
Pathways
NETPATH
REACTOME
REACT_206974
Insulin receptor signalling cascade pathway
REACT_213280
PKB-mediated events pathway
REACT_225366
IRS-related events triggered by IGF1R pathway
REACT_211999
Regulation of Rheb GTPase activity by AMPK pathway
REACT_216992
mTOR signalling pathway
REACT_212213
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
REACT_208835
IRS-related events pathway
REACT_217718
Translocation of GLUT4 to the plasma membrane pathway
REACT_224404
IRS-mediated signalling pathway
REACT_205176
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_216354
IGF1R signaling cascade pathway
REACT_214353
Signal Transduction pathway
REACT_209911
PI3K Cascade pathway
REACT_219546
Signaling by Insulin receptor pathway
REACT_209268
Regulation of AMPK activity via LKB1 pathway
REACT_221246
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_205675
Mitochondrial biogenesis pathway
REACT_213260
Membrane Trafficking pathway
REACT_219259
Organelle biogenesis and maintenance pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_22
Leptin pathway
REACTOME
REACT_21393
Regulation of Rheb GTPase activity by AMPK pathway
REACT_21285
Regulation of AMPK activity via LKB1 pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_21387
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_456
PKB-mediated events pathway
REACT_200686
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_11123
Membrane Trafficking pathway
REACT_220701
Regulation of AMPK activity via LKB1 pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_209837
Membrane Trafficking pathway
REACT_204167
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_257725
Regulation of Rheb GTPase activity by AMPK pathway
REACT_240139
PI3K Cascade pathway
REACT_243154
IRS-related events pathway
REACT_242206
IRS-mediated signalling pathway
REACT_188257
Signal Transduction pathway
REACT_255725
mTOR signalling pathway
REACT_256714
PKB-mediated events pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
KEGG
hsa04710
Circadian rhythm pathway
hsa04910
Insulin signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu04910
Insulin signaling pathway pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu04710
Circadian rhythm pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt Q5BIS9
TrEMBL A9QTH5 A9QU33 A9UIL4 A9UIM2 A9UIM4
UniProt Splice Variant
Entrez Gene 534107
UniGene Bt.20256
RefSeq NM_001024558 XM_005217881
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC150021 BT021145 EU259644 EU259647 EU259648 EU259649 EU259651 EU262640 EU262643 EU262644 EU262645 EU262646 EU310378 EU310379 EU310380 EU310381 EU310382 EU310386 EU310387 EU310388 EU310389 EU310390
GenPept AAI50022 AAX31327 ABX65311 ABX65314 ABX65315 ABX65316 ABX65318 ABX72030 ABX72033 ABX72034 ABX72035 ABX72036 ABX82666 ABX82667 ABX82668 ABX82669 ABX82670 ABX82673 ABX82674 ABX82675 ABX82676 ABX82677
RNA Seq Atlas 534107

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca