InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GHRHR

Summary

InnateDB Gene

IDBG-633389.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GHRHR

Gene Name

growth hormone-releasing hormone receptor precursor

Synonyms

GHRH-R; GHRHREC

Species

Bos taurus

Ensembl Gene

ENSBTAG00000047599

Encoded Proteins

IDBP-685117

growth hormone-releasing hormone receptor

IDBP-685118

growth hormone-releasing hormone receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106128:
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:65793129-65809031

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026967	ENSBTAP00000026967
ENSBTAT00000046224	ENSBTAP00000043543

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016520	growth hormone-releasing hormone receptor activity
GO:0017046	peptide hormone binding
GO:0019838	growth factor binding

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0008340	determination of adult lifespan
GO:0019933	cAMP-mediated signaling
GO:0021984	adenohypophysis development
GO:0030104	water homeostasis
GO:0030252	growth hormone secretion
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0030879	mammary gland development
GO:0032868	response to insulin
GO:0032869	cellular response to insulin stimulus
GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway
GO:0040018	positive regulation of multicellular organism growth
GO:0042445	hormone metabolic process
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
GO:0043627	response to estrogen
GO:0046887	positive regulation of hormone secretion
GO:0048469	cell maturation
GO:0051246	regulation of protein metabolic process
GO:0051384	response to glucocorticoid
GO:0060124	positive regulation of growth hormone secretion
GO:0060133	somatotropin secreting cell development

Cellular Component

GO:0005637	nuclear inner membrane
GO:0005640	nuclear outer membrane
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016363	nuclear matrix
GO:0030141	secretory granule