Version 5.4
Homo sapiens Gene: GHRHR
Summary
InnateDB Gene IDBG-11350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GHRHR
Gene Name growth hormone releasing hormone receptor
Synonyms GHRFR; GRFR; IGHD1B
Species Homo sapiens
Ensembl Gene ENSG00000106128
Encoded Proteins
IDBP-11354
growth hormone releasing hormone receptor
IDBP-11356
growth hormone releasing hormone receptor
IDBP-237945
growth hormone releasing hormone receptor
IDBP-294448
growth hormone releasing hormone receptor
IDBP-294441
growth hormone releasing hormone receptor
IDBP-810040
growth hormone releasing hormone receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30938669-30993254
Strand Forward strand
Band p14.3
Transcripts
ENST00000326139 ENSP00000320180
ENST00000337750 ENSP00000338184
ENST00000396227 ENSP00000379529
ENST00000409904 ENSP00000387113
ENST00000409316 ENSP00000386602
ENST00000466427
ENST00000489974
ENST00000461424
ENST00000461390
ENST00000463164
ENST00000473133
ENST00000611037 ENSP00000480159
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016520 growth hormone-releasing hormone receptor activity
GO:0017046 peptide hormone binding
GO:0019838 growth factor binding
Biological Process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007595 lactation
GO:0008150 biological_process
GO:0008284 positive regulation of cell proliferation
GO:0008340 determination of adult lifespan
GO:0019933 cAMP-mediated signaling
GO:0021984 adenohypophysis development
GO:0030104 water homeostasis
GO:0030252 growth hormone secretion
GO:0030816 positive regulation of cAMP metabolic process
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0030879 mammary gland development
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway
GO:0040018 positive regulation of multicellular organism growth
GO:0042445 hormone metabolic process
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043627 response to estrogen
GO:0046887 positive regulation of hormone secretion
GO:0048469 cell maturation
GO:0048609 multicellular organismal reproductive process
GO:0051246 regulation of protein metabolic process
GO:0051384 response to glucocorticoid
GO:0060124 positive regulation of growth hormone secretion
GO:0060133 somatotropin secreting cell development
Cellular Component
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016363 nuclear matrix
GO:0030141 secretory granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004654
View Gene Order
ENSBTAG00000047599
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18377
Glucagon-type ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.641194 Hs.767
RefSeq NM_000823
HUGO
OMIM
CCDS CCDS5432
HPRD 00748
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca