InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.25906

Summary

InnateDB Gene

IDBG-633422.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.25906

Gene Name

corticotropin-releasing factor receptor 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014381

Encoded Proteins

IDBP-685132

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106113:
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:66062161-66090181

Strand

Forward strand

Band

Transcripts

ENSBTAT00000046187

ENSBTAP00000043509

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0015056	corticotrophin-releasing factor receptor activity

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0016525	negative regulation of angiogenesis
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0071376	cellular response to corticotropin-releasing hormone stimulus

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane