Version 5.4
Bos taurus Gene: BT.76892
Summary
InnateDB Gene IDBG-633454.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.76892
Gene Name OTU domain-containing protein 7B
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001586
Encoded Proteins
IDBP-685168
OTU domain-containing protein 7B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18178551
[Homo sapiens] OTUD7B is a deubiquitinating enzyme that participate in the resolution of inflammatory responses by suppressing NF-kappaB.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
Gene Information
Type Protein coding
Genomic Location Chromosome 3:20656593-20712080
Strand Forward strand
Band
Transcripts
ENSBTAT00000021435 ENSBTAP00000021435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0008270 zinc ion binding
GO:0070530 K63-linked polyubiquitin binding
GO:1990380 Lys48-specific deubiquitinase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002385 mucosal immune response
GO:0016579 protein deubiquitination
GO:0032717 negative regulation of interleukin-8 production
GO:0035871 protein K11-linked deubiquitination
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:1900181 negative regulation of protein localization to nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
null
View Gene Order
ENSMUSG00000038495
View Gene Order
Cross-References
SwissProt
TrEMBL E1B9S7
UniProt Splice Variant
Entrez Gene 525579
UniGene Bt.76892
RefSeq NM_001144093
HUGO HGNC:16683
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02007270 DAAA02007271 DAAA02007272
GenPept
RNA Seq Atlas 525579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca