Version 5.4
Mus musculus Gene: Otud7b
Summary
InnateDB Gene IDBG-174459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Otud7b
Gene Name OTU domain containing 7B
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038495
Encoded Proteins
IDBP-174461
OTU domain containing 7B
IDBP-174463
OTU domain containing 7B
IDBP-174465
OTU domain containing 7B
IDBP-536653
OTU domain containing 7B
IDBP-532954
OTU domain containing 7B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18178551
[Homo sapiens] OTUD7B is a deubiquitinating enzyme that participate in the resolution of inflammatory responses by suppressing NF-kappaB.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
Gene Information
Type Protein coding
Genomic Location Chromosome 3:96104527-96161129
Strand Forward strand
Band F2.1
Transcripts
ENSMUST00000090785 ENSMUSP00000088291
ENSMUST00000035519 ENSMUSP00000046413
ENSMUST00000098849 ENSMUSP00000096449
ENSMUST00000138206 ENSMUSP00000121847
ENSMUST00000132980 ENSMUSP00000115699
ENSMUST00000146660
ENSMUST00000135263
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0008270 zinc ion binding
GO:0070530 K63-linked polyubiquitin binding
GO:1990380 Lys48-specific deubiquitinase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002385 mucosal immune response
GO:0006508 proteolysis
GO:0016579 protein deubiquitination
GO:0032717 negative regulation of interleukin-8 production
GO:0035871 protein K11-linked deubiquitination
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:1900181 negative regulation of protein localization to nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000001586
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.272336 Mm.401522
RefSeq NM_001025613 NM_001025614 XM_006501383 XM_006501384 XM_006501385 XM_006501386 XM_006501387 XM_006501388 XM_006501389 XM_006501390 XM_006501391 XM_006501392
OMIM
CCDS CCDS17629
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca