InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.68596

Summary

InnateDB Gene

IDBG-633507.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.68596

Gene Name

transcriptional activator Myb

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012074

Encoded Proteins

IDBP-685226

transcriptional activator Myb

IDBP-685230

transcriptional activator Myb

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118513:
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:74222882-74258203

Strand

Forward strand

Band

Transcripts

ENSBTAT00000016017	ENSBTAP00000016017
ENSBTAT00000045964	ENSBTAP00000043305

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006816	calcium ion transport
GO:0010468	regulation of gene expression
GO:0030183	B cell differentiation
GO:0045624	positive regulation of T-helper cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048538	thymus development
GO:0048566	embryonic digestive tract development
GO:0048872	homeostasis of number of cells
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0051574	positive regulation of histone H3-K9 methylation