Mus musculus Gene: Myb
Summary
InnateDB Gene IDBG-136895.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Myb
Gene Name myeloblastosis oncogene
Synonyms AI550390; c-myb; M16449;
Species Mus musculus
Ensembl Gene ENSMUSG00000019982
Encoded Proteins
myeloblastosis oncogene
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118513:
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:21124930-21160984
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000020158 ENSMUSP00000020158
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 14 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-dependent
GO:0006355 regulation of transcription, DNA-dependent
GO:0006816 calcium ion transport
GO:0010468 regulation of gene expression
GO:0030183 B cell differentiation
GO:0045624 positive regulation of T-helper cell differentiation
GO:0045892 negative regulation of transcription, DNA-dependent
GO:0045893 positive regulation of transcription, DNA-dependent
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048538 thymus development
GO:0048566 embryonic digestive tract development
GO:0048872 homeostasis of number of cells
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Prolactin pathway
REACTOME
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Notch-mediated HES/HEY network
AP-1 transcription factor network
C-MYB transcription factor network
IL2 signaling events mediated by PI3K
Cross-References
SwissProt P06876
TrEMBL Q3UUX5 Q8BTV4
UniProt Splice Variant
Entrez Gene 17863
UniGene
RefSeq NM_010848
OMIM
CCDS CCDS35861
HPRD
IMGT
MGI ID 97249 MGI:97249
MGI Symbol Myb
EMBL AC153556 AK088598 AK137794 BC011513 K03547 M12848 M13989 M20210 M21169 X02774 X04099 X04100 X04101 X04102 X04103 X04104 X16389 X16390
GenPept AAA39782 AAA39783 AAA39786 AAA39787 AAB59713 AAH11513 BAC40443 BAE23498 CAA26552 CAA27724 CAA34425 CAA34426
ImmGen Myb (murine)
RNA Seq Atlas 17863