Version 5.4
Bos taurus Gene: SLC10A2
Summary
InnateDB Gene IDBG-633554.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC10A2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005925
Encoded Proteins
IDBP-685285
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125255:
This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:83257177-83277101
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021363 ENSBTAP00000021363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008508 bile acid:sodium symporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0015721 bile acid and bile salt transport
Cellular Component
GO:0005902 microvillus
GO:0016020 membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000125255
View Gene Order
ENSMUSG00000023073
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11042
Recycling of bile acids and salts pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_267716
Orphan transporters pathway
REACT_111217
Metabolism pathway
REACT_239346
Recycling of bile acids and salts pathway
REACT_268398
Orphan transporters pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_229469
Bile acid and bile salt metabolism pathway
KEGG
hsa04976
Bile secretion pathway
mmu04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N5D8
UniProt Splice Variant
Entrez Gene 525823
UniGene
RefSeq
HUGO HGNC:10906
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02034800 DAAA02034801 DAAA02034802
GenPept
RNA Seq Atlas 101907090 525823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca