InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc10a2

Summary

InnateDB Gene

IDBG-131723.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc10a2

Gene Name

solute carrier family 10, member 2

Synonyms

ASBT; ISBT

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023073

Encoded Proteins

IDBP-131725

solute carrier family 10, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125255:
This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:5085623-5105232

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000023835

ENSMUSP00000023835

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008508	bile acid:sodium symporter activity

Biological Process

GO:0006814	sodium ion transport
GO:0015711	organic anion transport
GO:0015721	bile acid and bile salt transport
GO:0055085	transmembrane transport

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005902	microvillus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane